Drug Resistance Surveillance in Tuberculosis : Report of an Intercountry Training Workshop, Bangkok, 21–25 August 2000

Technical Session

Introduction of Participants and Pre-test

Before start of the session, the participants were provided with a questionnaire, designed to obtain the participants’ background, including their level of education and experience in laboratory practice, and to elicit their knowledge, attitude and practice (KAP).

A representative from each country made a brief presentation explaining the tuberculosis situation of their respective countries/regions and also the type of laboratory methods practiced. A few among them also presented available data on drug resistance.

 

Tuberculosis Incidence in South-East Asia

TB has been identified as a major killer disease accounting for more than 1 500 deaths daily in SEAR. With about 5% of global land area and 25 percent population, SEAR accounts for 42% of the global tuberculosis burden and one-third of global TB deaths Further, the contribution of HIV epidemic to this threat and increase in the prevalence of MDR-TB with a poor cure and higher mortality rate is a significant threat to TB control programmes. Although SEAR has made some pioneering contribution towards TB control such as methodology for conducting national sample survey; efficacy and feasibility of case-detection by sputum microscopy; successful outcome of home-based treatment; efficacy of intermittent chemotherapy and discovery of the principles of DOTS. Despite these contributions, there is continuous burden of TB in SEAR due to lack of political will and poor allocation of funds, inadequate and irregular supply of anti-TB drugs, poor quality of drugs, and lack of supervision. Since the control of TB by DOTS has proved effective in a big way, the importance of strengthening the key diagnostic methods such as sputum microscopy and other bacteriological diagnostic methods including determination of drug resistance profile was stressed. Since the level of initial drug resistance serves as an epidemiological marker of bacterial transmission in the community, it is important to follow internationally accepted methodology for setting up drug susceptibility testing including quality assurance to avoid wide variation in drug resistance as seen at present in Member Countries.

 

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