World Health Organization Regional Office for South-East Asia

Facts and Figures

ALZHEIMER'S DISEASE : The Brain Killer

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Historical Background

A rude shock...

A young man, Amit, was studying in the US. He had not been home for three years. He had heard that his grandfather was "growing old" but did not know that he was sick in any way.

The young man decided to visit his grandfather on his first day back home. He was met by the old faithful maid - the same maid who had helped bring him up. She hugged Amit, offered him a cup of tea and wanted to know all about him. Then she very quietly told him that his grandfather was not in the best of health but that she would call him. Mr B entered, shabbily dressed with his vest outside his shirt and looking frightened. He said that he had paid all his taxes and wanted to know why Amit had come to the house without an appointment. Mr B apparently did not remember Amit or that he was his favourite grandson. He kept calling Amit his brother. During dinner, the young man was surprised to see how his grandfather had aged: he was sloppy and made a mess of the food; slurped all the time; his previous impeccable table manners had disappeared. Finally, he got up after dessert, went to the corner of the room and relieved himself by ‘watering’ the potted plants. Amit was shocked.

Mr B soon went to bed. The maid of many years was embarrassed and unhappy. She told Amit that Mr B had been in this state for some twelve months. His memory, even for day-to-day things had faded. He could not remember telephone messages, would repeat himself incessantly, even demand breakfast and lunch a second and third time. He would try to take sexual liberties with her and, at the same time, accuse her of robbing him and letting thugs and crooks into his house. At times, when he was in a good mood, he would take her by the hand and introduce her to the fairies sitting on the window, then tell her to set the table and cook enough for the five fairies and themselves. His business affairs were in a shambles; yet, he tried to set up new companies and start projects which he promptly forgot. All in all, life was bad.

Amit was aghast. He took his grandfather to a doctor who referred him for special assessment by a team of doctors consisting of a neurologist, psychiatrist and psychologist. Certain tests were performed and a diagnosis of dementia due to Alzheimer’s disease was made.

Dementia, derived from the Latin word, [de-=out from + mens= the mind] means loss or impairment of mental powers due to a disease. The word démence existed in the French language as far back as 1381. It is generally understood today as the "loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning". This definition from the Diagnostic and Statistical Manual of the American Psychiatric Association of 1994 has a long and interesting history, which transcends generations and indeed civilizations.

The Egyptians and Greeks of the period 2000 - 1000 BC were well aware that advancing years and old age were associated with disorders of the memory. The Chinese used the words Zhi Dai Zheng for dementia and Lao Ren Zhi Dai Zheng for senile dementia which was described basically as a disease of old people characterized by muteness, lack of response and craziness. The Romans, i.e. AC Celsus and Claudius Galen of the first and second centuries AD, referred to chronic mental disorders known to produce an irreversible impairment of higher intellectual functions. The Ayurvedic physicians of India used the Sanskrit term Smriti Bhransh as early as 800 BC to describe loss of memory. Also, in India, the expressions satar-batar which literally translates to "turned 70" and another sathiya gaya which translates to "turned sixty" are used for old people. Research has indicated that these expressions are applied only to those older people

who show altered behaviour and loss of memory regardless of age. However, since this change most frequently happened in people at 60 or 70 years of age, the terms assumed a numerical connotation. In some parts of South India, the word Chinan, probably derived from the Dravidian languages, is used to refer to a condition associated with ageing, deterioration in memory, abnormal behaviour and occasional incontinence. While the concept of dementia in the aged is widely known in Thailand, Alzheimer’s disease also known as Roke Long is not as well recognized.

The changes brought on the mind by old age have also been recognized in the past. William Shakespeare refers to them in his plays "As You Like It", "Macbeth" and "King Lear" - the last written about 1606, aptly describes what is known even today as dementia.

Act 4, Scene 7:60-70

LEAR:
"Pray, do not mock me:
I am a very foolish fond old man,
Four score and upward, not an hour more nor less;
And, to deal plainly,
I fear I am not in my perfect mind.
Methinks I should know you, and know this man;
Yet I am doubtful: for I am mainly ignorant
What place this is; and all the skill I have
Remembers not these garments; nor I know not
Where I did lodge last night. Do not laugh at me;
For, as I am a man, I think this lady
To be my child Cordelia."

CORDELIA: "And so I am, I am."

 

 

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