World Health Organization Regional Office for South-East Asia

TB in South-East Asia

 

 

Key Milestones achieved in 2008

DOTS

The entire population in the Region now lives within access to DOTS facilities; The overall case detection rate reported in 2007 was 68.5%, close to the global target of 70%, and the overall treatment success rate for the cohort of new smear-positive cases initiated on treatment in 2006 was 87%. By the end of 2008, five* countries—Bhutan, DPR Korea, Maldives, Myanmar and Sri Lanka—had achieved or maintained both global targets for case detection and treatment success under DOTS, based on UN population figures for the Member countries.

Strengthening national laboratory networks

External quality assurance for smear microscopy is being strengthened in all Member countries through training of laboratory staff. Seven countries—

Bangladesh, India, Indonesia, Myanmar, Nepal, Sri Lanka, and Thailand—have at least one national-level laboratory with facilities for mycobacterial culture and drug susceptibility testing for the detection of MDR-TB cases. Bangladesh, Nepal and Sri Lanka are in the process of having their national reference laboratories accredited for quality assurance of culture and drug susceptibility testing, while additional reference laboratories are being accredited in India, Indonesia, Myanmar and Thailand.

Recognizing that TB-HIV co-infection must be addressed effectively, national HIV/AIDS and TB programmes in seven countries in the Region have developed national policies and strategies for TB-HIV. National level TB/HIV coordinating bodies have been established. The regional strategic framework for TB/HIV is also being revised and updated. TB/HIV activities are widely available in Thailand and are being expanded in India and Myanmar. India is implementing an intensified package of TB/HIV interventions in the nine states with a high HIV prevalence. There has been a more than 5 fold increase in referrals from HIV counselling and testing centres to the TB services and more than 3 fold increase in referrals from the TB to HIV services over the last 3 years. Indonesia, with a concentrated HIV epidemic, has established interventions in Papua and Java Bali, which are the country’s HIV high-prevalence areas. Cross-referrals between the TB and HIV programmes have been strengthened, and the TB recording and reporting systems in these countries revised to include information on TB/HIV co-infection.

Bangladesh, India, Nepal, and Timor-Leste have established MDR-TB case management under their national programmes. Nepal has recently expanded to all five regions in the country, while India is gradually expanding services to additional states. Indonesia and Myanmar are expected to begin enrolling MDR-TB patients in early 2009. Two countries, Bhutan and Sri Lanka, have submitted applications to the Green Light Committee and plan to commence MDR-TB case management in 2009.

National guidelines for the management of childhood TB were finalized in Bangladesh, Indonesia and Myanmar. Myanmar and Nepal received their first grants for anti-TB paediatric formulations through the Global Drug Facility (GDF), supported through UNITAID, while paediatric grants were approved for DPR Korea and Sri Lanka.

India is introducing infection control measures in health facilities while Indonesia, Myanmar and Thailand will undertake assessments and prepare infection control plans in 2009.

Countries have also included measures to address vulnerable populations at higher risk and cross-border issues in their national plans for TB control and Global Fund applications.

Public and private partnerships

TB technical working groups and/or specific task forces and sub-working groups have been established both at the regional and at national levels in Bangladesh, DPR Korea, India, Indonesia, Myanmar, and Nepal.

A major strategy towards improving case detection and treatment success rates has been the inclusion of public health care providers operating outside the Ministry of Health, such as the railways, military and prison health services, as well as private providers in all Member countries where patients seek services through the private health sector. The International Standards of TB Care were endorsed by professional bodies-- medical associations in India, Indonesia, Myanmar, and Nepal. Inter-sectoral collaboration and public-private partnerships for delivery of services were further scaled up in eight Member countries—Bangladesh, India, Indonesia, Myanmar, Nepal, Sri Lanka, Thailand and Timor-Leste. Over 350 medical colleges, 22 000 private practitioners, 1 500 large public and private hospitals, 150 corporate institutions, 2,500 nongovernmental organizations and 550 prisons are now working with national TB control programmes. Some recent initiatives in countries were formal inclusion of pre-service training on the principles and practices of TB control and establishing of referral mechanisms through providing lists of DOTS centres to teaching institutes, inclusion of private laboratories in diagnostic network and QA systems, and launching of “IMPACT” a coalition of professional associations for TB control, in India. In 2008, India also formally established a widely inclusive national partnership, becoming the second country in the Region to establish such a partnership, in addition to Indonesia. Indonesia intensified training of private and public hospital and laboratory staff and introduced coordination meetings between community health facilities and hospitals to improve transfer mechanisms between lung clinics and puskesmas. In Myanmar, services have been resumed throughout the network of PSI Sun Quality Clinics and the NTP plans further expansion of public/private mix services through the Myanmar Medical Association. There are also very encouraging examples of community-based approaches in several countries, but these need to be systematically documented and the experiences used to more widely replicate successful models at the national level.

Surveillance, monitoring and evaluation

TB prevalence and incidence were revised for Timor-Leste based on a review of more recent data and trends in cases notified and for DPR Korea based on an ARTI survey completed in 2007. Annual reports were received from all countries and are being used to finalize the Regional and WHO Global reports for 2009.

In five countries in the Region, drug resistance surveys were conducted or will continue through 2008-2009, to assess the extent of anti-TB drug resistance among TB patients. The overall rates of multi-drug resistant TB (MDR-TB) in the Region is 2.8 % among new smear-positive patients and 18.8% among previously treated patients.

Surveillance for HIV prevalence among TB patients is undertaken routinely in Thailand and in nine states in India. In Myanmar, Nepal, Sri Lanka and in the remaining states and union territories in India, data from sentinel surveys are used to follow trends in HIV prevalence among TB patients.

These surveys are contributing to more accurate estimations of the burden of disease. At the same time, countries are beginning to focus on mechanisms that will ensure that routine case notifications begin to reflect the disease magnitude and trends. Data management software was upgraded in Myanmar and Nepal and further improvements made in the Windows-based EPI centre software in India. Training on data management and analysis for central and international level programme staff were conducted in Bangladesh, India, Myanmar and Thailand.

The practice of quarterly and annual internal reviews and larger joint reviews every two/three years, inviting international experts for joint monitoring and evaluation together with national programmes and partners was continued. These have helped to objectively review the performance of the respective national TB programmes, and lead to substantial improvements in programme performance.

Resources

Domestic funding for TB control continues to account for over half of the funding for national TB control programmes. By the end of 2008, a total of 23 proposals were approved by the Global Fund in support of TB control programmes in the Region. In addition, nine Member countries benefit from funds from other development partners and donor governments with the exception of Bhutan and Maldives where the only external funds are through WHO country budgets.

All 11 Member countries continue to access quality-assured affordable anti-TB drugs on a regular basis through grants or direct procurement services of the Global Drug Facility.

Operational Research

National TB programmes and partners are engaged in carrying forward several operational research projects. Examples are public-private mix (PPM) models in India and Indonesia; field testing of new diagnostics and shorter treatment regimens in India; approaches to community-based TB care in Bangladesh, India, Indonesia, Thailand and Timor-Leste.

In addition, some support continues to be received through the small grants scheme under TDR. National workshops on operations research priority setting and dissemination are held regularly in India.

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