The Disease and its Treatment

 

  

 

 

The Disease

 

Lymphatic filariasis (LF) or elephantiasis is one of the most debilitating and disfiguring scourge among all diseases. It is a major public health problem in many South-East Asian countries. Nine out of the 11 countries in the Region are known to be endemic for filariasis. The infection is caused by helminthic worms inhabiting the lymphatics.

Elephantiasis of the leg

Elephantiasis of the right leg and swelling in the left

Lymphoedema of the arm.

 

All the three lymphatic filaria parasites viz. Wuchereria bancrofti, Brugia malayi and B. timori are prevalent in the Region. Bancroftian filariasis transmitted by the ubiquitous principal vector, Culex quinquefasciatus, is the most predominant infection in South Asia while Brugian infections transmitted by Mansonia and Anopheles vectors predominate in Indonesian Archipelago.

 


Life cycle of Wuchereria bancrofti

 

Lymphatic filariasis is one the only six infectious diseases considered eradicable by WHO with the available tools. Though the disease is not fatal, it is responsible for considerable morbidity causing social stigma among men, women and children. It is usually acquired during early childhood. It mainly afflicts poor people in both urban and rural areas.                                                      

The elimination of LF will contribute significantly in the reduction of LF morbidity, and thereby have a positive impact on improvement in reproductive health, enhancement of child nutrition and health and alleviation of sufferings of poverty stricken endemic populace countrywide. The programme envisages improvement in the overall national healthcare system and in the intra and intersectoral cooperation in uplifting multitudes of population above the poverty line.

Though some of the massive chronic manifestations are irreversible, if the programme is effectively implemented, it will augur marked reduction and ultimate interruption of transmission, thereby protecting the future generations from this scourge. Simple self-help methods of hygiene are shown to provide great relief and can prevent debilitating acute episodes.

 

 

 

The Treatment

 

The treatment strategy consists of two main components:

 

1.      Treatment of the community to progressively reduce and ultimately interrupt transmission

 

WHO recommends a 2-drug regimen of DEC + albendazole mass drug administration (MDA) to the entire endemic population once per year for 5-6 years.

Transmission can also be reduced by avoiding mosquito bites in endemic areas through personal protective measures like repellents, use of bed nets and insecticides.

Mosquito vectors often breed in stagnating polluted water bodies, such as blocked drains and sewers, and hence good sanitation is essential to reduce mosquito breeding places.

Integrated vector management and personal protection measures are useful complements to MDA.

 

2.      Treatment to prevent and alleviate disabilities due to LF

 

The common disabilities are lymphoedema, particularly of extremities in both males and females and hydrocoele in males.

Affected patients are empowered to effectively manage lymphoedema, through simple but rigorous hygiene techniques. Most patients with symptoms require lifelong therapy to alleviate lymphoedema. However, surgery provides a lasting cure for patients with hydrocoels. A public health approach is encouraged for hydrocelectomy.

 

WHO Guidelines:

*      Training module on community home-based prevention of disability due to lymphatic filariasis: Learner’s Guide

*      Training module on community home-based prevention of disability due to lymphatic filariasis: Tutor’s Guide

*      Community home-based prevention of disability due to lymphatic filariasis: Flipchart

 

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