During the past seven decades, antimicrobial agents have saved millions of lives, substantially reduced the burden of diseases that were previously widespread and improved the quality of life as well as helped increase life expectancy. Accordingly, these drugs were called “wonder drugs”. In the recent past, emergence and spread of resistance in several microorganisms has rendered the management of many infectious diseases difficult. Resistance poses a growing threat to the treatment and control of endemic, epidemic-prone as well as pandemic diseases. The development of resistance to drugs is also an impediment in achieving the Millennium Development Goals by 2015.