Global Leprosy Programme

Multi-drug therapy (MDT)

MDT treatment is provided in blister packs, each containing four weeks’ treatment. Specific blister packs are available for multibacillary (MB) and paucibacillary (PB) leprosy as well for adults and children.

Standard adult treatment regimen for MB leprosy:

  • Rifampicin: 600 mg once a month
  • Clofazimine: 300 mg once a month, and 50 mg daily
  • Dapsone: 100 mg daily

Duration: 12 months (12 blister packs)

Standard adult treatment regimen for PB leprosy:

  • Rifampicin: 600 mg once a month
  • Dapsone: 100 mg daily

Duration: six months (six blister packs)

Standard child (ages 10 – 14) treatment regimen for MB leprosy:

  • Rifampicin: 450 mg once a month
  • Clofazimine: 150 mg once a month, and 50 mg every other day
  • Dapsone: 50 mg daily

Duration: 12 months (12 blister packs)

Standard child (ages 10 – 14) treatment regimen for PB leprosy:

  • Rifampicin: 450 mg once a month
  • Dapsone: 50 mg daily

Duration: six months (six blister packs)

The appropriate dose for children under 10 years of age can be decided on the basis of body weight. [Rifampicin: 10 mg per kilogram body weight, clofazimine: 1 mg per kilogram per body weight daily and 6 mg per kilogram monthly, dapsone: 2 mg per kilogram body weight daily. The standard child blister pack may be broken up so that the appropriate dose is given to children under 10 years of age. Clofazimine can be spaced out as required.]

Rarely, it may be considered advisable to treat a patient with a high bacillary index (BI) for more than 12 months. This decision may only be taken by specialists at referral units after careful consideration of the clinical and bacteriological evidence.

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